Genetic Association Studies in Ischaemic Stroke
نویسندگان
چکیده
منابع مشابه
Genetic Association Studies in Stroke
Background and Purpose—A large number of candidate gene association studies have attempted to identify genes implicated in stroke, but there have been few replicable and robust associations reported. Summary of Review—The skantness of replicable associations partly relates to poor study design. Important methodological considerations include adequate sample size, the selection of appropriate co...
متن کاملMitochondrial DNA haplogroups and risk of transient ischaemic attack and ischaemic stroke: a genetic association study
BACKGROUND Genetic factors have a role in the pathogenesis of ischaemic stroke, but the main genes involved have yet to be defined. Mitochondrial mechanisms have been implicated in the pathophysiology of acute stroke, but the role of mitochondrial DNA (mtDNA) has not been comprehensively studied. We investigated whether there is an association between mtDNA haplotypes and incidence of stroke. ...
متن کاملGenetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies
BACKGROUND Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have been 3500 cases or less. We established the METASTROKE collaboration with the aim of validating associations from previous GWAS and identifying novel genetic associations through meta-analysis of GWAS datasets for ischaemic strok...
متن کاملGenomewide association studies of stroke.
BACKGROUND The genes underlying the risk of stroke in the general population remain undetermined. METHODS We carried out an analysis of genomewide association data generated from four large cohorts composing the Cohorts for Heart and Aging Research in Genomic Epidemiology consortium, including 19,602 white persons (mean [+/-SD] age, 63+/-8 years) in whom 1544 incident strokes (1164 ischemic s...
متن کاملGenetic association studies.
To the Editor: I am delighted to see that Arteriosclerosis, Thrombosis, and Vascular Biology has taken the lead in initiating an open discussion about genetic association studies in such a prominent manner. As correctly pointed out in the editorial by Dr Hegele,1 the number of publications has exponentially increased in the last decade. Despite the intrinsic problems with this approach, this ex...
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ژورنال
عنوان ژورنال: Cerebrovascular Diseases
سال: 2009
ISSN: 1015-9770,1421-9786
DOI: 10.1159/000199467